Fibrinogen Activity

Profile or Test Panel
Method Clottable
Test Information The Clauss thrombin-fibrinogen clotting reaction is determined in the presence of excess thrombin. Since the plasma is diluted, the polymerization of the fibrin monomer is rate limiting. The clotting time obtained is considered proportional to the fibrinogen concentration. Low fibrinogen values may be associated with disseminated intravascular coagulation (DIC), liver disease, or congenital hypo- or dysfibrinogenemia. Since fibrinogen is an acute phase reactant elevated levels are associated with stress or inflammation.
Additional Test Information Normal range: 250-450 mg/dl
Sample Requirements Whole Blood:  3.2% Sodium Citrated (blue top)  OR
Frozen Plasma
Requested Volume Two 5 ml 3.2 sodium citrated (blue top) tubes as whole blood  OR
Frozen plasma in 4 X 1mL aliquots in plastic tubes 
Sample Information Whole blood is preferred for testing but if it is not possible to send whole blood tubes TO ARRIVE HERE within 3 hours of collection then send frozen plasma:  Centrifuge blue top tubes at 1500g for 15 minutes and remove the plasma and centrifuge a second time at 1500g for an additional 15 minutes.  Aliquot approximately 1 ml of plasma into 4 plastic tubes, and freeze.  
Shipping Information Whole Blood:  Send at ambient temperature (18-25C) and must be received within the lab in less than or equal to 3 hours after collection.
Frozen Plasma:  send on dry ice 

Send samples to:

Bloodworks Northwest
Attn: Hemostasis Laboratory
921 Terry Ave
Seattle, WA 98104

For additional information please see Ordering Information
Requisition Form RFT- Hemostasis Reference Laboratory
Transaction Code 3200-08
CPT Codes 85384
Turn around Time (analytic time) 5 Business Days
Report/ Results Fax number required to receive report