David Motto Laboratory

Our laboratory is interested in the biochemistry, physiology, and genetics of blood clotting diseases and endothelial cells (the cellular lining of blood vessels).

We have a strong current focus on the thrombotic microangiopathies (TMAs), which are characterized clinically in people by small blood vessel thrombosis (blood clots) of various organs, coupled with thrombocytopenia (low blood platelets) and the physical destruction of red blood cells.  Our laboratory studies TMAs both using cultured endothelial cells in vitro, and also with an animal model that closely resembles the human disease thrombotic thrombocytopenic purpura (TTP), which still has a mortality rate greater than 20%.

Areas of study

  • Roles of VWF, ADAMTS13, platelets, and endothelial injury in TMAs
  • Mechanisms of endothelial injury leading to hemostasis and thrombosis
  • Role of red blood cells in hemostasis and thrombosis


  • Joined BloodworksNW as an Associate Member in 2013
  • 2006–2013: Assistant Professor, Departments of Internal Medicine, Pediatrics, and Anatomy and Cell Biology, University of Iowa
  • 2003-2006: Lecturer in Pediatric Hematology/Oncology, University of Michigan
  • 2000-2003: Fellow Physician, Pediatric Hematology/Oncology, University of Michigan
  • 1998-2000: Resident Physician, Department of Pediatrics, University of Michigan
  • 1996-1998: Postdoctoral Fellow, University of Iowa
  • 1996: MD and PhD (Physiology and Biophysics) from the University of Iowa



David G. Motto, MD, PhD
Associate Member

Bloodworks Northwest
Research Institute
1551 Eastlake Avenue E, Suite 100
Seattle, WA 98102

Phone: (206) 568-2200
Fax: (206) 587-6056

Rachel Sessum
Administrative Specialist
Phone: (206) 568-2244
Fax: (206) 587-6056
eFax: (866) 287-7208