Post Transfusion Purpura (PTP) Workup

Also Known as (Alias) PTP
Method Flow Cytometry, Polymerase Chain Reaction (PCR), Enzyme Linked Immunosorbant Assay (ELISA)
Test Information Strong positive antibody results against platelets from random donors and the absence of common platelet antigens in the patient are indicative of PTP.
Additional Test Information Post-transfusion Purpura (PTP) can occur in patients who have been previously sensitized to platelets by transfusion or through pregnancy. Transfusion of cellular blood products containing any platelets (e.g., platelets, granulocytes or red blood cell transfusions) induce a recall of a previously formed alloantibody against platelet specific antigen(s) between 5-10 days post-transfusion. In the process of recalling the alloantibody, the patient apparently also develops a transient autoantibody that leads to the destruction of the patient’s own platelets often resulting in severe thrombocytopenia.
Sample Requirements Please contact Platelet Immunology Laboratory at 206-689-6543 for sample and drug requirements
Sample Information Samples must be received Monday thru Friday morning.  Samples received after 10:00am on Friday or over the weekend will have to be re-drawn.
Shipping Information Send whole blood specimens at ambient temperature. Specimens should arrive in the lab within 24 hours from draw time.

Send samples to:
Bloodworks Northwest
Attn:  Platelet Immunology Lab, Rm 619
921 Terry Avenue
Seattle, WA 98104

For additional information, please see Ordering Information

Requisition Form RFT- Platelet Immunology Laboratory
Transaction Code 3660-00
CPT Codes 81105, 81106, 81107, 81108, 81109, 81110, 81111, 81112, 86022 x6, 86023 x4, 86832 x1
Test Schedule As requested
Turn around Time (analytic time) 1 business day for antibody screen
5 business days for additional testing
Report/Results Fax number required to receive report

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