Factor XIII Screen
|Profile or Test Panel
|Factor XIII forms covalent cross links between fibrin chains. In the absence of Factor XIII, the fibrin clot will be dissolved by 5 M urea which disrupts the hydrogen bonds. This assay will be abnormal only if the factor XIII level is <2-5%. Hereditary factor XIII deficiency, an autosomal recessive disorder, should be suspected in a patient with delayed post-surgical or traumatic bleeding, unexplained CNS hemorrhage. Women with severe FXIII deficiency have difficulty maintaining pregnancy.
|Additional Test Information
|Normal ranges are included on testing report and can be made available upon request.
|Whole Blood: 3.2% sodium citrated (blue top) OR
|Two 5 ml 3.2% sodium citrated (blue top) tubes as whole blood OR
frozen plasma in 4 X 1mL aliquots in plastic tubes
|Minimum Volume or Pediatric Volume
|Frozen Plasma: at least 0.5ml in 2 plastic tubes.
|Whole blood is preferred for testing, but if it is not possible to send whole blood tubes TO ARRIVE HERE WITHIN 2 HOURS of collection, then send frozen plasma. To prepare plasma, centrifuge blue top tubes at 1500g for 15 minutes and remove the plasma and centrifuge a second time at 1500g for an additional 15 minutes. Aliquot approximately 1 ml of plasma into 4 plastic tubes, and freeze.
|Whole Blood: Send at ambient temperature (18-25°C) and must be received within the lab in less than or equal to 2 hours after collection.
Frozen Plasma: Send on dry ice
Send samples to:
For additional information, please see Ordering Information
|RFT- Hemostasis Reference Laboratory
|Turn around Time (analytic time)
|Fax number required to receive report