|Profile or Test Panel|
|Test Information||Factor XIII forms covalent cross links between fibrin chains. In the absence of Factor XIII, the fibrin clot will be dissolved by 5 M urea which disrupts the hydrogen bonds. This assay will be abnormal only if the factor XIII level is <2-5%. Hereditary factor XIII deficiency, an autosomal recessive disorder, should be suspected in a patient with delayed post-surgical or traumatic bleeding, unexplained CNS hemorrhage. Women with severe FXIII deficiency have difficulty maintaining pregnancy.|
|Additional Test Information||Normal Range: insoluble in urea|
|Sample Requirements||Whole Blood: 3.2% Sodium Citrated (blue top) OR
|Requested Volume||Two 5 ml 3.2 sodium citrated (blue top) tubes as whole blood OR
Frozen plasma in 4 X 1mL aliquots in plastic tubes
|Minimum Volume or Pediatric volume||Frozen Plasma: at least 0.5ml in 2 plastic tubes.|
|Sample Information||Whole blood is preferred for testing but if it is not possible to send whole blood tubes TO ARRIVE HERE WITHIN 3 HOURS of collection then send frozen plasma. To prepare plasma centrifuge blue top tubes at 1500g for 15 minutes and remove the plasma and centrifuge a second time at 1500g for an additional 15 minutes. Aliquot approximately 1 ml of plasma into 4 plastic tubes, and freeze.|
|Shipping Information||Whole Blood: Send at ambient temperature (18-25C) and must be received within the lab in less than or equal to 3 hours after collection.
Frozen Plasma: send on dry iceSend samples to:
For additional information, please see Ordering Information
|Requisition Form||RFT- Hemostasis Reference Laboratory|
|Turn around Time (analytic time)||5 Business Days|
|Report/ Results||Fax number required to receive report|
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