Pavel Davizon-Castillo, M.D.
Dr. Davizon-Castillo’s lab seeks to understand why and how platelets are programmed to cause pathological clotting during inflammatory stress. His research focuses on the role of inflammatory molecules causing our bone marrow cells to switch the way platelets are made. Instead of operating as normal, these switched platelets promote blood clots unnecessarily, endangering the patient. This research includes studying the normal and abnormal changes of platelets throughout human aging (from children to older adults) and from pathological conditions such as rheumatoid arthritis, obesity, sickle cell disease, diabetes, cardiovascular diseases, and other aging-associated hematological diseases like Myeloproliferative Neoplasms (MPNs).
Areas of Study
- Megakaryocyte and platelet biology
- Immunometabolism of megakaryocyte and platelets
- Clinical work towards caring for children with bleeding, platelet disorders and thrombosis
Dr. Davizon-Castillo’s Background
- 07/2017 – 06/2019: Instructor, Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplant, University of Colorado, Denver, CO
- 08/2019 – 07/2023: Assistant Professor, Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplant, University of Colorado, Denver, CO
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