The Genomics Testing Laboratory primarily performs molecular testing to identify genetic mutations and polymorphisms for Red Cell antigens.
Using molecular methods it is possible to identify genetic variations that control expression of red cell antigens on the cell surface. This can be done using patient, amniocyte or a blood donor DNA; intact red cells are not needed. Some examples of uses for genomic testing of red cell blood groups include:
In potential cases of hemolytic disease of the fetus and newborn (HDFN) blood group genomic testing can determine fetal blood group typing to help guide fetal monitoring during pregnancy.
Paternal zygosity of the father of the fetus is a modality that can predict the fetal red cell phenotype. Most red cell antigens including RhD are now available.
Bloodworks Northwest performs DNA-based tests for the fields of Red Cell Blood Groups, Hemostasis/Thrombosis, Hemophilia, Platelets, HLA, and Neutrophils. These molecular tests are powerful tools in the treatment and diagnosis of certain disorders. Other DNA-based tests can be found at specific laboratory sites which are listed below.
Most HLA testing, particularly HLA testing for transplantation, involves performing a number of different tests. Persons requesting HLA testing should refer to Profile Descriptions to determine the tests to be ordered and the specimen requirements.
Limitations of Molecular Typing of Red Cells
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