Bloodworks Northwest performs molecular testing to identify genetic variants and polymorphisms. We perform DNA-based tests for the fields of Red Cell Blood Groups, Hemostasis/Thrombosis, Hemophilia, Platelets, HLA, and Neutrophils. These molecular tests are powerful tools in the treatment and diagnosis of certain disorders.
The Genetics Testing Laboratory performs molecular testing for Bleeding Disorders and Red Cell Genomics.
The Genetics Testing laboratory for Bleeding Disorders evaluates patients with known or suspected Hemophilia A, Hemophilia B and Von Willebrand disease. The laboratory features considerable technical expertise in this specialized testing.
Highlights of our genetic test offerings:
Using molecular methods it is possible to identify genetic variations that control expression of red cell antigens on the cell surface. This can be done using patient, amniocyte or a blood donor DNA; intact red cells are not needed. Some examples of uses for genomic testing of red cell blood groups include:
In potential cases of hemolytic disease of the fetus and newborn (HDFN) blood group genomic testing can determine fetal blood group typing to help guide fetal monitoring during pregnancy.
Paternal zygosity of the father of the fetus is a modality that can predict the fetal red cell phenotype. Most red cell antigens including RhD are now available.
Limitations of Molecular Typing of Red Cells
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