DNA Factor V Leiden (APC Resistance) Mutation

Profile or Test Panel
Also Known as (Alias) FV Leiden genotyping
Method polymerase chain reaction (PCR) based
Test Information Factor V Leiden Mutation (hereditary APC Resistance; Factor V “Leiden”, Dahlback, 1995) is a single point mutation of guanine (G) to adenine (A) at position 1691 of the factor V gene. This results in a substitution of glutamine for arginine at amino acid 506 resulting in Factor V Leiden and rendering it partially resistant to inactivation by APC. Their relative risks of venous thrombosis (vs. control) are about 7- and 80-fold (Rosendaal et al., 1995).
Additional Test Information Test Values:
Homozygous glutamine (Gin506)
Heterozygous or Homozygous arginine (Arg506) abnormal values
*Note abnormal tests are confirmed by repeating tests.
Sample Requirements EDTA (lavender top)
Requested Volume 5cc EDTA (lavender top) tube
Minimum Volume or Pediatric volume 5cc EDTA (lavender top) tube
Shipping Information Whole blood shipped at ambient temperature and should arrive in the lab within 48 hours.

Send samples to:
Bloodworks Northwest
Eastlake SDL
1551 Eastlake Ave E.
Seattle, WA 98102

For additional information please see Ordering Information

Requisition Form Request for Testing Hemostasis Reference Laboratory
Transaction Code 3250-03
CPT Codes 81241
Test Schedule Weekly on Tuesdays on samples received Wednesday through Monday noon
Turn around Time (analytic time) 3 business days
Report/Results Fax number required to receive report

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