|Profile or Test Panel|
|Also Known as (Alias)||FV Leiden genotyping|
|Method||polymerase chain reaction (PCR) based|
|Test Information||Factor V Leiden Mutation (hereditary APC Resistance; Factor V “Leiden”, Dahlback, 1995) is a single point mutation of guanine (G) to adenine (A) at position 1691 of the factor V gene. This results in a substitution of glutamine for arginine at amino acid 506 resulting in Factor V Leiden and rendering it partially resistant to inactivation by APC. Their relative risks of venous thrombosis (vs. control) are about 7- and 80-fold (Rosendaal et al., 1995).|
|Additional Test Information||Test Values:
Homozygous glutamine (Gin506)
Heterozygous or Homozygous arginine (Arg506) abnormal values
*Note abnormal tests are confirmed by repeating tests.
|Sample Requirements||EDTA (lavender top)|
|Requested Volume||5cc EDTA (lavender top) tube|
|Minimum Volume or Pediatric volume||5cc EDTA (lavender top) tube|
|Shipping Information||Whole blood shipped at ambient temperature and should arrive in the lab within 48 hours.
Send samples to:
|Requisition Form||Request for Testing Hemostasis Reference Laboratory|
|Test Schedule||Weekly on Tuesdays on samples received Wednesday through Monday noon|
|Turn around Time (analytic time)||3 business days|
|Report/Results||Fax number required to receive report|
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