Konkle Laboratory

Barbara A. Konkle, M.D.

“It’s exciting to take our research findings and translate them into clinical care.” Barbara A. Konkle, MD

The Konkle laboratory is focused on improving health by better diagnosis and treatment of bleeding and clotting disorders. Dr. Konkle’s recent research relates to improved testing for von Willebrand disease (VWD) and hemophilia, blood-clotting in pregnancy and other disorders, and cardiovascular disease in men with hemophilia.

Areas of Study

  • von Willebrand disease and Hemophilia
  • Sickle Cell Disease
  • Thrombosis (unwanted blood clotting) in pregnancy
  • Cardiovascular disease in hemophilia

Dr Konkle’s Background

Konkle Laboratory

The Konkle laboratory conducts clinical and translational research studies in hemostasis and thrombosis.

Areas of Study

von Willebrand Factor (VWF) and von Willebrand Disease (VWD)
Dr. Konkle’s research in this area relates to improved testing for VWD and changes of VWF and factor VIII (FVIII) in pregnancy in normal women and women with VWD. Her studies of VWF in pregnancy include collaborations with Dr. Jill Johnsen at Bloodworks Northwest and Dr. Hilary Gammill at the University of Washington. In collaboration with Drs. Jose Lopez and Dong they are evaluating VWF genetic variations, bleeding symptoms and laboratory measures of function in patients with and without VWD.

Genomics in Hemophilia
Dr. Konkle leads a nationwide project to determine the causitive genetic variant in hemophilia A and B and to establish a Research Repository linked to the ATHN clinical database for future research. A portion of repository specimens are undergoing whole genome sequencing through the NHLBI Transomics in Precision Medicine (TOPMed) program. The project is governed by a collaboration of Bloodworks, ATHN, the National Hemophilia Foundation and Biogen.

N-acetylcysteine (NAC) in Sickle Cell Disease and Thrombotic Thrombocytopenia Purpura (TTP)
In collaboration with and building on findings by Dr. lopez, we are leading clinical studies of NAC in patients with Sickle Cell Disease, including during painful crises. Data suggest that NAC treatment can decrease adhesive VWF and modulate red blood cell adhesion. We are also studying NAC in TTP.

Cardiovascular Disease in Men with Hemophilia
With improved treatments, the life expectancy of men with hemophilia is approaching that of the general population. The downside of that great advance is the occurrence of heart attacks as these men age, despite their low clotting factor. With funding from the CDC, Dr. Konkle and colleagues across the U.S. are further evaluating cardiovascular disease in hemophilia.

Clinical Trials of Treatments for Hemophilia and Other Disorders
Dr. Konkle has a longstanding interest in the evaluation of new treatments for bleeding and clotting disorders and has participated in multiple NIH, CDC and industry-sponsored trials of new therapies including gene therapy. At Bloodworks Northwest, in collaboration with Dr. Rebecca Kruse-Jarres, they are evaluating new treatments for hemophilia and von Willebrand disease. We have evaluated costs and quality of life issues in hemophilia through the Hemophilia Utilization Group Study and coagulation factor utilization and other data analyses through the American Thrombosis and Hemostasis Network.

Representative Publications

Click here to view.

Konkle Team Members

  Sarah Ruuska, MPH
Clinical Research Program Manager
Email: sarahru@bloodworksnw.org
Phone, Central: (206) 689-6193
FAX: (866) 286-1053
  Angela Dove
Clinical Research Coordinator
Email: AngelaDo@bloodworksnw.org
Phone: (206) 568-2160
FAX: (206) 587-6056
  Shelley Fletcher
Genomics Testing Specialist
Email: ShelleyN@bloodworksnw.org
Phone: (206) 568-2207
  Sarah Galdzicka
Clinical Research Coordinator
Email: sarahg@bloodworksnw.org
Phone: (206) 689-6196
FAX: (866) 845-9812
  Sarah Heidl
Research Technologist II
E-mail: SarahH@BloodworksNW.org
Phone (206) 568-2233
Fax (206) 587-6056
  Haley Huston
Research Technologist III
E-mail: HaleyH@BloodworksNW.org
Phone (206) 568-2241
Fax (206) 587-6056
  Maggie Moore, RN
Clinical Research Nurse
Email: maggiem@bloodworksnw.org
Phone: (206) 689-6195
FAX: (877) 847-4743
  Sarah Roberge, MPH
Clinical Research Coordinator
Email: sarahr@bloodworksnw.org
Phone: (206) 568-2225
  Sarah Ryan, MS, CGC
Genetic Counselor
Email: Sryan@bloodworksnw.org
Phone: (541) 484-9112 ext 120
Fax: (855) 710-7943
  Sophie Schmitter
Clinical Research Coordinator
Email: SophieS@bloodworksnw.org
Phone: (206) 689-6539
  Ann Whitney
Administrative Specialist II
E-mail: AnnW@BloodworksNW.org
Phone (206) 689-6192
Fax (866) 632-9920

Barbara A. Konkle, M.D.
Associate Chief Scientific Officer
Bloodworks Northwest

Director,
Hemostasis, Platelet Immunology, and Genomics
Bloodworks Northwest

Professor of Medicine/Hematology,
University of Washington

Bloodworks Northwest
921 Terry Avenue
Seattle, WA 98104

Email: barbarak@bloodworksnw.org
UW Mailstop 359190
Phone: 206-689-6191

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